Methadone Clinics in Greenville, South Carolina
2 SAMHSA-certified opioid treatment programs operate inside Greenville city limits. Each clinic below carries a current NPI on the CMS Medicare Provider OTP file. We list the operator-stated phone next to our verified intake line so you choose how to make contact.
2 verified clinics in Greenville
Metro Treatment OF South Carolina
Greenville at a glance
71,755
Residents
30.3 sq mi
Land area
34.8
Median age
$68,460
Median household income
9.6%
Uninsured (civilian)
8.9%
Families below poverty
Source: U.S. Census Bureau, ACS 5-year estimates (2023).
Overdose context for Greenville County
Greenville County reported a model-based drug poisoning death rate of 40.9 per 100,000 residents in 2021 (95% CI 39.1 to 42.8). That sits 43.7% above the national county mean of 28.5 per 100,000.
201927.3
202035.4
202140.9
Three-year change (27.3 to 40.9): +13.5 per 100,000.
County-level estimates are reported at the county level, not the city level. Source: NCHS Drug Poisoning Mortality by County (CDC dataset rpvx-m2md), 2019 to 2021 model-based estimates. NCHS urban/rural classification: Medium Metro.
Closest methadone clinic to Greenville
Nearest verified opioid treatment program in South Carolina: Ascent Recovery Solutions in Simpsonville, about 10.4 miles (16.8 km) from Greenville by straight-line distance. Driving time will run longer.
Why this matters for treatment access
Greenville County ran a 2021 drug poisoning death rate of 40.9 per 100,000, well above the national county mean of 28.5. About 9.6% of residents are uninsured. Most clinics in the area accept Medicaid; confirm before scheduling intake. That works out to roughly 6,888 uninsured residents in Greenville alone.
What to ask before you call
Methadone is a daily-dose program. That changes the questions you should be asking. Run through these before you commit to a clinic:
- What time does dosing start, and what time does it close? Daily methadone often means a 6am window five or six days a week.
- Which insurance plans do you bill? Medicaid coverage for OTPs varies by state plan and managed-care organization.
- How long does intake take from first call to first dose? In some states it is same-day. In others it can run a week.
- What is your take-home schedule? Federal rules let stable patients earn take-home doses over time. Clinic policy on how fast you earn them differs.
- Do you offer counseling on-site or do I coordinate it elsewhere?
If the in-city options do not fit
Closest alternative inside South Carolina: Ascent Recovery Solutions in Simpsonville, about 10.4 miles from Greenville. Office-based buprenorphine is also available locally and does not require daily clinic visits.
Nearby cities with methadone clinics
Duncan (1 · 14.4km) Simpsonville (1 · 15.5km) Easley (1 · 29.3km) Spartanburg (2 · 29.4km) Clinton (1 · 50.2km)
Need office-based treatment instead of a daily-dosed OTP? Many providers in Greenville prescribe buprenorphine in office settings. See Suboxone providers in Greenville.
Want a non-opioid alternative? See South Carolina Vivitrol providers for monthly extended-release naltrexone.
State-level access scoring, regulatory context, and the full directory live on the South Carolina methadone hub.