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Methadone Clinics in San Francisco, California

6 SAMHSA-certified opioid treatment programs operate inside San Francisco city limits. Each clinic below carries a current NPI on the CMS Medicare Provider OTP file. We list the operator-stated phone next to our verified intake line so you choose how to make contact.

San Francisco, California

6 verified clinics in San Francisco

City AND County OF SAN Francisco

1001 POTRERO AVE, San Francisco, CA 94110 · Directions
SAMHSA-certified OTP per CMS-OTP-2026-01-05. NPI 1578787925.

San Francisco at a glance

836,321
Residents
46.7 sq mi
Land area
39.7
Median age
$141,446
Median household income
3.5%
Uninsured (civilian)
5.7%
Families below poverty

Source: U.S. Census Bureau, ACS 5-year estimates (2023).

Overdose context for San Francisco County

San Francisco County reported a model-based drug poisoning death rate of 52.6 per 100,000 residents in 2021 (95% CI 51 to 54.3). That sits 84.8% above the national county mean of 28.5 per 100,000.

201935.2
202045.6
202152.6

Three-year change (35.2 to 52.6): +17.4 per 100,000.

County-level estimates are reported at the county level, not the city level. Source: NCHS Drug Poisoning Mortality by County (CDC dataset rpvx-m2md), 2019 to 2021 model-based estimates. NCHS urban/rural classification: Large Central Metro.

Closest methadone clinic to San Francisco

Nearest verified opioid treatment program in California: Marin Treatment Center in San Rafael, about 32.9 miles (52.9 km) from San Francisco by straight-line distance. Driving time will run longer.

Why this matters for treatment access

San Francisco County ran a 2021 drug poisoning death rate of 52.6 per 100,000, well above the national county mean of 28.5. Uninsured rates here run low (3.5%), so commercial insurance acceptance matters. Ask each clinic which payers they bill. That works out to roughly 29,271 uninsured residents in San Francisco alone.

What to ask before you call

Methadone is a daily-dose program. That changes the questions you should be asking. Run through these before you commit to a clinic:

If the in-city options do not fit

Closest alternative inside California: Marin Treatment Center in San Rafael, about 32.9 miles from San Francisco. Office-based buprenorphine is also available locally and does not require daily clinic visits.

Nearby cities with methadone clinics

Need office-based treatment instead of a daily-dosed OTP? Many providers in San Francisco prescribe buprenorphine in office settings. See Suboxone providers in San Francisco.

Want a non-opioid alternative? See California Vivitrol providers for monthly extended-release naltrexone.

State-level access scoring, regulatory context, and the full directory live on the California methadone hub.