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Methadone Clinics in Chicago, Illinois

20 SAMHSA-certified opioid treatment programs operate inside Chicago city limits. Each clinic below carries a current NPI on the CMS Medicare Provider OTP file. We list the operator-stated phone next to our verified intake line so you choose how to make contact.

Chicago, Illinois

20 verified clinics in Chicago

Family Guidance Centers INC

1220 SOUTH WOOD ST, Chicago, IL 60608 · Directions
SAMHSA-certified OTP per CMS-OTP-2026-01-05. NPI 1447847413.

Healthcare Alternative Systems, INC

4734 W CHICAGO AVE, Chicago, IL 60651 · Directions
SAMHSA-certified OTP per CMS-OTP-2026-01-05. NPI 1801097100.

Human Resources Development Institu

340 E 51ST ST, Chicago, IL 60615 · Directions
SAMHSA-certified OTP per CMS-OTP-2026-01-05. NPI 1033397369.

Pilsen-Little Village Community MEN

3113 W CERMAK RD, Chicago, IL 60623 · Directions
SAMHSA-certified OTP per CMS-OTP-2026-01-05. NPI 1578787644.

Chicago at a glance

2,707,648
Residents
227.7 sq mi
Land area
35.7
Median age
$75,134
Median household income
9.8%
Uninsured (civilian)
13%
Families below poverty

Source: U.S. Census Bureau, ACS 5-year estimates (2023).

Overdose context for Cook County

Cook County reported a model-based drug poisoning death rate of 33.2 per 100,000 residents in 2021 (95% CI 32.6 to 33.8). That sits 16.6% above the national county mean of 28.5 per 100,000.

201922.2
202028.8
202133.2

Three-year change (22.2 to 33.2): +11 per 100,000.

County-level estimates are reported at the county level, not the city level. Source: NCHS Drug Poisoning Mortality by County (CDC dataset rpvx-m2md), 2019 to 2021 model-based estimates. NCHS urban/rural classification: Large Central Metro.

Closest methadone clinic to Chicago

Nearest verified opioid treatment program in Illinois: Soft Landing Interventions, LLC in Palos Heights, about 12.6 miles (20.3 km) from Chicago by straight-line distance. Driving time will run longer.

Why this matters for treatment access

Cook County reports a 2021 drug poisoning death rate of 33.2 per 100,000, slightly above the national county mean of 28.5. About 9.8% of residents are uninsured. Most clinics in the area accept Medicaid; confirm before scheduling intake. That works out to roughly 265,350 uninsured residents in Chicago alone.

What to ask before you call

Methadone is a daily-dose program. That changes the questions you should be asking. Run through these before you commit to a clinic:

If the in-city options do not fit

Closest alternative inside Illinois: Soft Landing Interventions, LLC in Palos Heights, about 12.6 miles from Chicago. Office-based buprenorphine is also available locally and does not require daily clinic visits.

Nearby cities with methadone clinics

Need office-based treatment instead of a daily-dosed OTP? Many providers in Chicago prescribe buprenorphine in office settings. See Suboxone providers in Chicago.

Want a non-opioid alternative? See Illinois Vivitrol providers for monthly extended-release naltrexone.

State-level access scoring, regulatory context, and the full directory live on the Illinois methadone hub.