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Methadone Clinics in Santa Ana, California

1 SAMHSA-certified opioid treatment program operates inside Santa Ana city limits. Each clinic below carries a current NPI on the CMS Medicare Provider OTP file. We list the operator-stated phone next to our verified intake line so you choose how to make contact.

Santa Ana, California

1 verified clinic in Santa Ana

California Treatment Services LLC

2101 E 1ST ST, Santa Ana, CA 92705 · Directions
SAMHSA-certified OTP per CMS-OTP-2026-01-05. NPI 1215030861.

Santa Ana at a glance

311,639
Residents
27.4 sq mi
Land area
34.3
Median age
$88,354
Median household income
12.4%
Uninsured (civilian)
8.8%
Families below poverty

Source: U.S. Census Bureau, ACS 5-year estimates (2023).

Overdose context for Orange County

Orange County reported a model-based drug poisoning death rate of 24.7 per 100,000 residents in 2021 (95% CI 24.1 to 25.3). That sits 13.4% below the national county mean of 28.5 per 100,000.

201916.5
202021.3
202124.7

Three-year change (16.5 to 24.7): +8.2 per 100,000.

County-level estimates are reported at the county level, not the city level. Source: NCHS Drug Poisoning Mortality by County (CDC dataset rpvx-m2md), 2019 to 2021 model-based estimates. NCHS urban/rural classification: Large Central Metro.

Closest methadone clinic to Santa Ana

Nearest verified opioid treatment program in California: Western Pacific Re-Hab in Costa Mesa, about 6 miles (9.7 km) from Santa Ana by straight-line distance. Driving time will run longer.

Why this matters for treatment access

Orange County reports a 2021 drug poisoning death rate of 24.7 per 100,000, modestly below the national county mean of 28.5. Roughly 12.4% of residents lack health insurance, which is high enough that you should ask each clinic about sliding-scale fees and Medicaid acceptance before you commit. That works out to roughly 38,643 uninsured residents in Santa Ana alone.

What to ask before you call

Methadone is a daily-dose program. That changes the questions you should be asking. Run through these before you commit to a clinic:

If the in-city options do not fit

Closest alternative inside California: Western Pacific Re-Hab in Costa Mesa, about 6 miles from Santa Ana. Office-based buprenorphine is also available locally and does not require daily clinic visits.

Need office-based treatment instead of a daily-dosed OTP? Many providers in Santa Ana prescribe buprenorphine in office settings. See Suboxone providers in Santa Ana.

Want a non-opioid alternative? See California Vivitrol providers for monthly extended-release naltrexone.

State-level access scoring, regulatory context, and the full directory live on the California methadone hub.