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Methadone Clinics in San Jose, California

2 SAMHSA-certified opioid treatment programs operate inside San Jose city limits. Each clinic below carries a current NPI on the CMS Medicare Provider OTP file. We list the operator-stated phone next to our verified intake line so you choose how to make contact.

San Jose, California

2 verified clinics in San Jose

County OF Santa Clara

2101 ALEXIAN DR, STE A&B, San Jose, CA 95116 · Directions
SAMHSA-certified OTP per CMS-OTP-2026-01-05. NPI 1649313859.

County OF Santa Clara

2425 ENBORG LN, San Jose, CA 95128 · Directions
SAMHSA-certified OTP per CMS-OTP-2026-01-05. NPI 1912041922.

San Jose at a glance

990,054
Residents
177.9 sq mi
Land area
38.1
Median age
$141,565
Median household income
4.9%
Uninsured (civilian)
4.9%
Families below poverty

Source: U.S. Census Bureau, ACS 5-year estimates (2023).

Overdose context for Santa Clara County

Santa Clara County reported a model-based drug poisoning death rate of 16.8 per 100,000 residents in 2021 (95% CI 16.2 to 17.5). That sits 40.8% below the national county mean of 28.5 per 100,000.

201911.3
202014.6
202116.8

Three-year change (11.3 to 16.8): +5.6 per 100,000.

County-level estimates are reported at the county level, not the city level. Source: NCHS Drug Poisoning Mortality by County (CDC dataset rpvx-m2md), 2019 to 2021 model-based estimates. NCHS urban/rural classification: Large Central Metro.

Closest methadone clinic to San Jose

Nearest verified opioid treatment program in California: Addiction Research AND Treatment IN in Menlo Park, about 22.3 miles (35.9 km) from San Jose by straight-line distance. Driving time will run longer.

Why this matters for treatment access

Santa Clara County reports a 2021 drug poisoning death rate of 16.8 per 100,000, materially below the national county mean of 28.5. Uninsured rates here run low (4.9%), so commercial insurance acceptance matters. Ask each clinic which payers they bill. That works out to roughly 48,513 uninsured residents in San Jose alone.

What to ask before you call

Methadone is a daily-dose program. That changes the questions you should be asking. Run through these before you commit to a clinic:

If the in-city options do not fit

Closest alternative inside California: Addiction Research AND Treatment IN in Menlo Park, about 22.3 miles from San Jose. Office-based buprenorphine is also available locally and does not require daily clinic visits.

Need office-based treatment instead of a daily-dosed OTP? Many providers in San Jose prescribe buprenorphine in office settings. See Suboxone providers in San Jose.

Want a non-opioid alternative? See California Vivitrol providers for monthly extended-release naltrexone.

State-level access scoring, regulatory context, and the full directory live on the California methadone hub.